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This is a wonderful and timely book. The era of artificial intelligence and machine learning and their roles and contributions to the practice and advancement of medicine is still at its very early stages. This book offers an extensive review of the most recent efforts in that regard. Eric Topol is a great writer, with a clear clinician’s insight into the potential effects of AI and machine learning in the medical practice. He discusses critical aspects including medical education, the patient-physician relationship, the practice of medicine in specific fields such as oncology and cardiology, as well as those specialties that have a big role of pattern recognition such as pathology, radiology, ophthalmology, and dermatology.